Abstract: With the advancement of shale gas drilling to deeper reservoirs, the density of drilling fluid has approached 1.75 g/cm³, and the density of cement slurry approached 1.85-1.89 g/cm³. To improve the quality of well cementing and prevent the losses of cement slurry, the pressure bearing capacity of the open hole to oil base drilling fluids should be improved. The application of an imported new lost circulation material (LCM) for use in oil base mud on the deep shale gas well Jiaoye-XX (a well drilled in the second phase of shale gas development in Fuling, Sichuan) showed that the oil base mud LCM is able to plug lost circulation zones while drilling, and imposes no negative effect on the rheology of the drilling fluid. The pressure bearing capacity of part of the lost circulation zones was enhanced, from pressure bearing capacity of 1.75 g/cm³ to 1.80 g/cm³. Finally, all the lost circulation zones had their pressure bearing capacity enhanced. Using the imported LCM and an oil base mud LCM T150 of independent intellectual property rights, the pressure bearing capacity of the formations prone to lost circulation was enhanced to 1.85 g/cm³. Study results showed that control of oil base mud losses with the two strongly LCMs is widely applicable and easy to operate. The two strongly lipophilic LCMs are a worth popularizing in controlling oil base mud losses.